651 Microbiome-free fatty acid cross-talk in the human pilosebaceous gland
نویسندگان
چکیده
منابع مشابه
Positive and Negative Cross-Talk between Lysophosphatidic Acid Receptor 1, Free Fatty Acid Receptor 4, and Epidermal Growth Factor Receptor in Human Prostate Cancer Cells.
Lysophosphatidic acid (LPA) is a lipid mediator that mediates cellular effects via G protein-coupled receptors (GPCRs). Epidermal growth factor (EGF) is a peptide that acts via a receptor tyrosine kinase. LPA and EGF both induce proliferation of prostate cancer cells and can transactivate each other's receptors. The LPA receptor LPA1 is particularly important for LPA response in human prostate ...
متن کاملHuman Microbiome
Humans are almost identical in their genetic pattern, but the slight differences in our DNA lead to remarkable phenotypic variation among the human population. There are a variety of microbial communities and their genes (microbiomes) in the human body that play an essential role in human health and disease. The microbes inhabiting our bodies is quite a bit more variable, with only a third of i...
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Myocardial substrate metabolism was studied in 13 subjects at the time of diagnostic cardiac catheterization by means of palmitic acid-(14)C infusion with arterial and coronary sinus sampling. Two subjects were considered free of cardiac pathology and all, with one exception, demonstrated lactate extraction across the portion of heart under study. Data for this single lactate-producing subject ...
متن کاملIdentification of fatty acids and fatty acid amides in human meibomian gland secretions.
PURPOSE The complex superficial lipid layer of the tear film functions to prevent evaporation and maintain tear stability. Although classes of lipids found in the tear film have been reported, individual lipid species are currently being studied with more sophisticated. METHODS The purpose of this work was to show the identification of fatty acids and the fatty acid amides in human meibomian ...
متن کاملThe regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids.
The short term regulation of fatty acid biosynthesis has been studied using primary cultures of human shin fibroblasts. These cells show rapid changes in rates of acetate incorporation into fatty acids depending upon the lipid content of the medium. When cells are incubated in medium containing lipid-deficient fetal calf serum overnight and then are switched to Eagle’s minimum essential medium,...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.02.673